Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury
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چکیده
منابع مشابه
Changes in Urinary Bladder Structure and Systemic Inflammation Response Following Incomplete Transection versus Contusion Spinal Cord Injury in Rat Model
Objective- The current study was conducted to evaluate changes in the urinary bladder structure and leukocyte profile as an important index of the systemic inflammation response for two different types of spinal cord injury (SCI) in a rat model. Design- Experimental Study.Animals- Forty adult healthy female Sprague-Dawley rats.<br /...
متن کاملCytoskeletal disruption following contusion injury to the rat spinal cord.
Following experimental spinal cord injury (SCI), there is a delayed loss of neurofilament proteins but relatively little is known regarding the status of other cytoskeletal elements. The purpose of the present study was to compare the extent and time course of the MAP2 loss with that of neurofilament proteins, and to examine tau protein levels and distribution following SCI. Within 1 to 6 hours...
متن کاملenhanced neuropathic pain following intraspinaly injection of schwann cells in contusion model of spinal cord injury
enhanced neuropathic pain following intraspinaly injection of schwann cells in contusion model of spinal cord injury pourheydar b [1] *, joghataei mt [2] , najafzadeh n [3] received: 6 nov , 2011 accepted: 20 jan , 2012 abstract background & aims : spinal cord injury (sci) leads to sensorimotor deficits and neuropathic pain (np). cell therapy is a common method for treatment of sc...
متن کاملSpatio-Temporal Progression of Grey and White Matter Damage Following Contusion Injury in Rat Spinal Cord
Cellular mechanisms of secondary damage progression following spinal cord injury remain unclear. We have studied the extent of tissue damage from 15 min to 10 weeks after injury using morphological and biochemical estimates of lesion volume and surviving grey and white matter. This has been achieved by semi-quantitative immunocytochemical methods for a range of cellular markers, quantitative co...
متن کاملThermostabilized chondroitinase ABC Promotes Neuroprotection after Contusion Spinal Cord Injury
Background: Chondroitinase ABC (cABC), due to its loosening impact on the extracellular matrix scaffold, has been used to enhance regeneration of injured axonal tracts after spinal cord injury (SCI). However, cABC thermal instability at physiological temperature has limited its clinical application. The disaccharide trehalose has been shown to increase the stability of cABC in body temperature....
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2014
ISSN: 0969-7128,1476-5462
DOI: 10.1038/gt.2014.74